Calcium/calmodulin-dependent serine protein kinase （CASK） is a conserved multi-domain scaffolding protein involved in brain development，synapse formation，and establishment of cell polarity. CASKINs （CASK interacting proteins） interact with CASK and are thought to play a role in CASK function，specifically by coupling CASK to distinct downstream effectors. CASKIN1 is a multidomain protein containing six N-terminal ankyrin repeats，one SH3 domain，and two sterile alpha motif domains followed by a long proline-rich sequence and a short conserved C-terminal domain. CASKIN1 co-assembles with CASK on the cytoplasmic tail of neurexin 1，suggesting that CASKIN and CASK coat the cytoplasmic tails of neurexins and other cell-surface proteins.
应用类型
Western Blot: 1 - 2 ug/ml， ELISA. However， the optimal conditions should be determined individually.
免疫原
CASKIN1 antibody was raised against a 17 amino acid peptide near the center of human CASKIN1.
