Glial cell line-derived neurotrophic factor (GDNF) has been identified as a potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons. GDNF is a glycosylated，disulfide-bonded homodimer. It promotes the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. On the basis of these findings，it has been sμggested that GDNF may play a role in the treatment of Parkinson’s disease，which is marked by progressive degeneration of midbrain dopaminergic neurons.
应用类型
Western blotting, Immunoprecipitation, Immunohistochemistry
免疫原
Synthetic peptide surrounding amino acid 195 of mouse GDNF
