TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2，form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1； upon induction of autophagy，these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy，while their depletion triggers it，suggesting that TAB2 and TAB3 act as a control point for autophagy.
应用类型
Immunohistochemistry: 5 ug/ml， ELISA. However， the optimal conditions should be determined individually.
免疫原
TAB3 antibody was raised against a 13 amino acid peptide near the amino terminus of human TAB3.
