Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases，such as RIP and DAP kinase，are mediators of apoptosis. DAP kinase （DAPK） is pro-apoptotic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFNγ induced apoptosis. A novel DAP kinase-related protein was recently identified and designated DAPK2 and DRP-1. Ectopicly expressed DAPK2 induced apoptosis in various types of cells. DAPK has high sequence homology to ZIP kinase and DRAK1/2，and they represent a novel family of serine/threonine kinases，which mediates apoptosis through their catalytic activities. The messenger RNA of DAPK2 is expressed in multiple human syndrome.
应用类型
Immunohistochemistry: 2 ug/ml； Western Blot: 0.5 – 1 ug/ml； ELISA. However， the optimal conditions should be determined individually.
免疫原
Human DAP kinase 2 peptide corresponding to amino acids near the CT of DAPK2.
