Accumulation of the amyloid-beta peptide （Abeta） in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The beta-amyloid protein precursor （APP） is cleaved by beta-secretase，producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment （C99）. The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide （Abeta），which is deposited in the brains of all suffers of Alzheimer’s disease.
应用类型
Immunohistochemistry: 10 ug/ml； Western Blot: 0.5 – 1 ug/ml； ELISA. However， the optimal conditions should be determined individually.
免疫原
A peptide corresponding to the amino terminus of the 4K Ab peptide generated by b- and g-secretases from the amino acids of human amyloid A4 protein precursor （APP）.
