Increasing evidence sμggests a central role for the CD40L-CD40 signaling pathway in several immunogenic and inflammatory processes，including atherosclerosis. It was also found that CD40L-CD40 signaling pathways play an important role in several autoimmune diseases，including the X-linked hyper-IgM syndrome，collagen-induced arthritis，allergic encephalitis and multiple sclerosis，and acute and chronic graft vs. host diseases.
