Phosphatidylinositol 3-kinase (PI 3-kinase)，is a phosphoinositide-specific protein kinase that plays a central role in mitogenic signal transduction leading to cellular regulation，cell growth and differentiation，and oncogenesis. PI 3-kinase associates with，and is activated by a wide range of tyrosine kinase receptors including EGF，PDGF，CSF-1，erbB-3 and insulin receptor，non-receptor protein-tyrosine kinases of the src family (e.g. pp60src)，and crk and abl proto-oncogene products. PI 3-kinase is involved in signal transduction in terminally differentiated，activated cells like platelets and neutrophils.
应用类型
Western blot, Immunohistochemistry
免疫原
Synthetic peptide surrounding amino acid 505 of mouse P13 kinase.
