AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. It appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. AMPK alpha1，a member of the Ser/Thr protein kinase family，is a catalytic subunit of AMPK.
应用类型
Western blot
免疫原
Synthetic peptide surroundign amino acid 486 of human AMPK alpha 1
