AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. It appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5’-AMP rises in response to fuel limitation and/or hypoxia. AMPK alpha1，a member of the Ser/Thr protein kinase family，is a catalytic subunit of AMPK.
应用类型
The antibody can be used for Western blotting （1–4 ug/ml）.
免疫原
Synthetic peptide surroundign amino acid 486 of human AMPK alpha 1
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的AMPK⍺1蛋白发生免疫反应
保存建议
提供的200 ug AMPK⍺1抗体产品为无色溶液其浓度为0.5 mg/ml溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该AMPK⍺1抗体产品置于-20 °C冷冻保存，建议分装使用以避免反复冻融.
