The neurotransmitter/hormone adrenaline (epinephrine，adrenalin) plays a central role in the mammalian stress response，increasing heart rate，raising blood pressure，and increasing blood glucose levels. Adrenaline activates both alpha-adrenergic receptors and beta-adrenergic receptors. There are mainly three subtypes of beta adrenergic receptors known，beta1，beta2， and beta3. These receptors are expressed primarily in the heart，respiratory tissue，and adipose tissue. Beta3-receptors are abundant in brown adipocytes and play vital roles in lipolysis and thermoregulation. Beta adrenergic receptors are gaining much interest among researches in the studies of type-2 diabetes mellitus and obesity. It is also being considered as a therapeutic target for heart failure.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 405 of rat Beta3-AR
