The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma，which permits the interaction of this protein with multiple transcription factors. This protein can interact with，and regulate the activities of cAMP response element binding protein （CREB） and nuclear respiratory factors （NRFs）. It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis，and is a major factor that regulates muscle fiber type determination. This protein may also be involved in controlling blood pressure，regulating cellular cholesterol homoeostasis，and the development of obesity.
应用类型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Jurkat cell lysate can be used as a positive control.
免疫原
Synthetic peptide surrounding amino acid 766 of mouse PGC-1alpha
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的PGC-1alpha蛋白发生免疫反应.
保存建议
提供的PGC-1alpha抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该PGC-1alpha抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
