The PAK （p21-activated kinase） family of serine/threonine kinases plays an important role in multiple cellular processes，including cytoskeletal reorganization，MAPK signaling，apoptotic signaling，etc. PAK 5 is known for promoting neurite outgrowth and thus predominantly expressed in the brain. PAK 5 contains CDC42/Rac1and has shown to bind CDC42 in the presence of GTP. PAK 5 also plays an important role in inhibiting apoptotic cascade through BAD phosphorylation.
应用类型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody recognizes ~80 kDa of Pak5/PAK7 from samples of human， mouse， rat and dog origins. Reactivity to other species has not been determined.
免疫原
Synthetic peptide surrounding amino acid 90 of human PAK5/PAK7
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠、狗种属来源的PAK5/PAK7蛋白发生免疫反应.
保存建议
提供的PAK5/PAK7抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5 % BSA和0.01%硫柳汞的PBS， pH 7.2）缓冲液中.请将该PAK5/PAK7抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
