The PAK (p21-activated kinase) family of serine/threonine kinases plays an important role in multiple cellular processes，including cytoskeletal reorganization，MAPK signaling，apoptotic signaling，etc. Several mechanisms that induce PAK activation have been reported. Binding of Rac/cdc42 to the CRIB (or PBD) domain at the N-terminal region of PAK causes autophosphorylation and conformational change of PAK. More recently identified members PAK4，PAK5 and PAK6 have lower sequence similarity with PAK1-3 in the regulatory N-terminal region.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 552 of mouse Pak6
