Sp transcription factor family has a highly conserved DNA-binding domain composed of zinc fingers. The Sp family is comprised of Sp1，Sp2，Sp3 and Sp4 that regulates transcription by binding to consensus GC- and GT-box regulatory elements in the target genes. Sp1，Sp3 and Sp4 have a high binding capacity for GC box while Sp2 binds weakly to the GT box. Sp3 has been shown to have to a bifunctional transcription factor that can either stimulates or represses the transcription of various genes.
应用类型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Other applications have not been tested. The antibody detects ~86-100 kDa Sp3 in samples from human， mouse and rat origins.
免疫原
Synthetic peptide surrounding amino acid 766 of mouse Sp3
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的Sp3蛋白发生免疫反应.
保存建议
提供的Sp3抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该Sp3抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
