Stearoyl-CoA desaturase （SCD） is a regulatory enzyme involved in the synthesis of oleate and palmitoleate. Oleate and palmitoleate are the main components of membrane phospholipid，triglycerides and cholesterol esters. SCD plays an important role in cellular cholesterol homeostasis and also in the secretion processes of triacylglycerol and phospholipid. Inhibition of SCD could be a useful treatment for metabollic disorders such as obesity and hepatic steatosis.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody recognizes ~61 kDa ECM-1 of human， mouse， and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to residues surrounding amino acids 546 of mouse ECM-1
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的ECM蛋白发生免疫反应.
保存建议
提供的ECM抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该ECM抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
