Low density lipoprotein receptors （LDLR） are cell surface glycoproteins that regulate LDL cholesterol by scavenging LDL from the blood. LDLR is characterized by a cluster of cysteine-rich class A repeats，EGF-like repeats，the O-linked sugars domain and six YWTD or class B repeats. Mutations in the LDLR gene cause autosomal dominant disease such as familial hypercholesterolemia （FH） and atherosclerosis.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes mature LDLR （160 kDa）， LDLR precursor （120 kDa） and LDLR monomer （~50 kDa）.
免疫原
Synthetic peptide corresponding to residues surrounding amino acids 850 of human LDLR
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠、牛、仓鼠种属来源的LDLR蛋白发生免疫反应.
保存建议
提供的LDLR抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该LDLR抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
