Non-T cell Activation Linker （NTAL） is also known as linker for activation of B cells （LAB），is a transmembrane adaptor protein. NTAL is expressed in B cells，mast cells，monocytes and NK cells. When NTAL is tyrosine phosphorylated，it recruits signalling molecules such as Grb2，Gab2 and c-Cbl into receptor-signalling complexes. Mutation in the NTAL gene may cause Williams-Beuren syndrome，a rare genetic disorder.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody detects a 22 kDa rat NTAL/LAB. Other species have not been determined.
免疫原
Synthetic peptide surrounding amino acid 187 of rat NTAL
来源宿主
兔
反应性
经检测验证，可与大鼠种属来源的NATL/LAB蛋白发生免疫反应.
保存建议
提供的NATL/LAB抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞nn的PBS （pH 7.2）缓冲液中.请将该NATL/LAB抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
