CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T （Th2-type） cells. In contrast to other chemokine receptors，the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover，activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine.
应用类型
Western blotting （2-6 ug/ml）. However， the optimal concentrations should be determined individually.
免疫原
Synthetic peptide surrounding amino acid 32 of human CCR4
来源宿主
兔
反应性
经检测验证，可与人、小鼠、狗种属来源的CCR4蛋白发生免疫反应.
保存建议
提供的CCR4抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该CCR4抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
