AAK1 is a serine/threonine kinase that is thought to coordinate the recruitment of AP-2 to receptors containing tyrosine-based internalization motifs by phosphorylating the u2 subunit. There is strong evidence that this protein is the endogenous mu 2 kinase and plays a regulatory role in clathrin-mediated endocytosis，including the regulation of fatty acid synthesis and cholesterol synthesis.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes ~95 kDa AAK1 in samples from human， mouse and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 850 of human AAK1
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的AAK1蛋白发生免疫反应.
保存建议
提供的AAK1抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该AAK1抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
