LDL-related proteins，LRP-5 and LRP-6，are members of the LDL receptor superfamily，which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP-5 to Axin，leading Axin degradation and B-catenin stabilization.
应用类型
Western blot analysis （1-2 ug/ml）. However， the optimal conditions should be determined individually. Detects full length and a proteolytic fragment of LRP-6.
免疫原
Synthetic peptide derived from human LRP-6
来源宿主
小鼠
反应性
经检测验证，可与人、小鼠种属来源的LRP-5/6蛋白发生免疫反应.
保存建议
提供的LRP-5/6抗体产品为100 ug 无色溶液，其浓度为1.0 mg/ml，溶解于包含有0.15 M NaCl， 25%甘油， 0.5% BSA和0.01%叠氮钠的10 mM Tris-glycine （pH 7.0）缓冲液中.请将该LRP-5/6抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
