The proto-oncogene Pim1 belongs to a family of serine/threonine protein kinases that are highly conserved throμgh evolution in multicellular organisms. Pim1 is involved in the control of cytokine-mediated cell proliferation，differentiation and survival of lymphoid and myeloid cells as well as others. Expression of Pim1 can be stimulated by a variety of growth factors and is regulated at four different levels: transcriptional，post-transcriptional，translational and post-translational. Recently，Pim1 has been shown to enhance the activities of p100，c-Myb and Cdc 25a and in part this might explain reported effects of Pim1 on mitogenesis.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 296 of rat PIM1
