The proto-oncogene Pim1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Pim1 is involved in the control of cytokine-mediated cell proliferation，differentiation and survival of lymphoid and myeloid cells as well as others. Expression of Pim1 can be stimulated by a variety of growth factors and is regulated at four different levels: transcriptional，post-transcriptional，translational and post-translational. Recently，Pim1 has been shown to enhance the activities of p100，c-Myb and Cdc 25a and in part this might explain reported effects of Pim1 on mitogenesis.
应用类型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody recognizes ~33 kDa of PIM1 isoform from samples of human， mouse and rat origins. Reactivity to other species has not been determined.
免疫原
Synthetic peptide surrounding amino acid 296 of rat PIM1
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的PIM1蛋白发生免疫反应.
保存建议
提供的PIM1抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5 % BSA和0.01%硫柳汞的PBS， pH 7.2）缓冲液中.请将该PIM1抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
