Stem Cell Factor （SCF） is a glycoprotein that plays a key role in hematopoiesis acting both as a positive and negative regulator，often in synergy with other cytokines. SCF binds to and activates the SCF receptor （SCFR），a receptor tyrosine kinase. SCF stimulates the proliferation of mast cells and is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. It also mediates cell- cell adhesion and acts synergistically with other cytokine. Source：Recombinant protein corresponding to aa26-189 from human SCF，expressed in E. coli.Molecular Weight： ~18.5kD （165aa），confirmed by MALDI-TOFEndotoxin： <1EU/1ug （determined by LAL method）Biological Activity：Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is ≤10ng/ml.AA Sequence：MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVAStorage and Stability：May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product，centrifuge the original vial after thawing and prior to removing the cap.
