LDL-related proteins LRP-5 and LRP-6. are members of the LDL receptor superfamily，which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Induced-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Want proteins. Recent work also shows that Want proteins induce the binding of LRP-5 to Axin，leading Axin degradation and B-catenin stabilization.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. Jurkat cell lysate （Cat.# 2401-100） can be used as a positive control. The antibody recognizes the ~170 kDa full length LRP-5/6 of human and mouse origins. A cleavage fragment （~120 kDa） can also be detected. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 437 of human LRP
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的LRP-5/6蛋白发生免疫反应.
保存建议
提供的LRP-5/6抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该LRP-5/6抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
