HNF-4 (Hepatocyte nuclear factor 4)，a member of the steroid/thyroid nuclear receptor superfamily，is a transcriptional factor which expresses in the liver，intestine，kidney，and pancreatic cells. It contains several functional domains: a ligand-independent activation domain (AF1)，a zinc finger DNA binding domain，and a ligand-dependent activation domain (AF2). HNF-4 binds to a specific DNA element as a homodimer and regulates the expression of many genes，involved in glucose，fatty acid，and cholesterol metabolisms.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 454 of rat HNF
