COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID （Nonsteroidal anti-inflammatory drugs） such as aspirin. Prostaglandins （PGs） formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throughout the body，whereas PGs formed by COX-2 primarily mediate pain，fever，and inflammation. COX-1 is constitutively expressed，with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. In rodents and humans，COX-3 encodes proteins with completely different amino acid sequences than COX-1 or COX-2 and without COX activity. It has been suggested COX-3 as the key to unlocking the mystery of the mechanism of action of acetaminophen.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually.
免疫原
Synthetic peptide mapping to the N-terminus of mouse Cox-3
来源宿主
兔
反应性
经检测验证，可与小鼠种属来源的Cox-3蛋白发生免疫反应.
保存建议
提供的Cox-3抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该Cox-3抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
