Lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1)，also known as oxidized low-density-lipoprotein receptor-1 (OLR-1)，belongs to the C-type lectin family. LOX-1 binds and supports the internalization of multiple structurally unrelated macromolecules including oxidized LDL，advanced glycation end products (AGE)，activated platelets，bacteria，apoptotic or aged cells，and heat shock proteins. Human LOX-1 gene encodes a 273 amino acid residues (aa) protein with a short N-terminal intracellular domain，a transmembrane domain，an extracellular stalk/neck region followed a C-type lectin-like domain (CTLD). The expression of LOX-1 is induced by proinflammatory or proatherogenic stimuli，as well as by oxidized LDL itself and hemodynamic or oxidative stress. LOX-1-dependent oxidized LDL uptake also induces apoptosis by inducing the expression of the pro-apoptotic Bax and downregulation of the anti-apoptotic Bcl-2.
应用类型
Western blot, Immunohistochemistry
免疫原
Synthetic peptide near the N-terminus of human Lox-1
