Liver X receptors （LXRs） are oxysterol activated nuclear receptors which are involved in the regulation of genesis and metabolism of cholesterols and bile acids. LXRs form heterodimeric complexes with the retinoic acid receptors （RARs） once activated by their respective oxysterol ligands. Two known isoforms，alpha and beta，are differentially expressed； the alpha isoform predominantly expressed in liver，whereas beta isoform expression has been shown to be ubiquitous.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Other applications have not been determined. The antibody detects 49 kDa LXR alpha and beta subunits of human， mouse， rat and bovine LXR. Cross-reactivity to other species has not been determined. Jurkat cell lysate （Cat.# 2401-100） and mouse small intestine tissue lysate （Cat.# 2601-100） can be used as positive controls.
免疫原
Synthetic peptide surrounding amino acid 435 of human LXR
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的LXR蛋白发生免疫反应.
保存建议
提供的LXR抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该LXR抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
