The annexin family of calcium-binding proteins is composed of at least ten mammalian genes. It is characterized by a conserved core domain which binds to phospholipids in a Ca2+-dependent manner. Annexin family members have been implicated as regulators of diverse processes as ion flux，endocytosis and exocytosis，and cellular adhesion. Annexin VIII is preferentially expressed in acute promyelocytic leukemia （APL） cells which may relate its role in hematopoietic cell differentiation.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Jurkat cell lysate （Cat.# 2401-100） can be used as a positive control. The antibody detects 36 kDa annexin VIII of human origin. The ~28-30 kDa cleavage fragments can also be detected in Jurkat cell lysate
免疫原
Synthetic peptide surrounding amino acid 316 of human Annexin VIII
