PAX genes encode nuclear transcription factors that may function as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine PAX genes underlie three natural mouse alleles and several corresponding human syndromes （aniridia，foveal hypoplasia and Peters’ anomaly）. Murine PAX genes have been shown to be proto-oncogenes. Furthermore，human PAX genes have recently been demonstrated to play an influential part in some common human cancers such as brain tumors and lymphomas. All PAX genes encode a DNA-binding domain termed the paired domain and in addition some also encode a second binding domain--the paired type homeobox. PAX6 is involved in the early development of the optical vesicle and has been shown to interact with Six3，another important visual development protein.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody recognizes ~32 kDa and 47 kDa isoforms of PAX6 in samples from human， mouse and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 303 of rat PAX6
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的PAX6蛋白发生免疫反应.
保存建议
提供的PAX6抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该PAX6抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
