The nucleosome is made up of four core histone proteins (H2A,H2B,H3 and H4) and is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranscriptional modification including acetylation,phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression.
应用类型
Western blot, Immunoprecipitation
免疫原
Synthetic peptide corresponding to the N-terminus of human Histone H2B