HDAC family members have been divided into two classes. Class I of the HDACs comprises four members，HDAC-1，2，3，and 8，each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDACs comprises HDAC-4，5，6，and 7，the molecular weights of which are all about two-fold larger than those of the class I members，and the deacetylase domains are present within the C-terminal regions，except that HDAC-6 contains two copies of the domain，one within each of the N-terminal and C-terminal regions. Human HDAC-1，2 and 3 were expressed in various tissues，but the others (HDAC-4，5，6，and 7) showed tissue-specific expression patterns.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 25 of human HDAC-9
