HDAC3 is a member of the class I mammalian histone deacetylase family，which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC3 is composed of 428 amino acid residues. HDAC3 interacts with a growing number of transcriptional factors including SMRT and N-CoR. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions.
应用类型
Western blotting （0.5-4 ug/ml）and Immunohistochemistry （20-30 ug/ml）. However， the optimal conditions should be determined individually.The antibody detects the 49 kDa HDAC3. It does not cross-react with other HDAC proteins including HDAC1， 2， 4， 5， 6， 7， and 8. Jurkat cell lysate （Cat.# 2401-100） can be used as a positive control.
免疫原
Synthetic peptide corresponding to the C-terminus of human HDAC-3
