The Voltage-Dependent Anion Channel （VDAC or mitochondrial Porin）I is an outer membrane mitochondrial protein. The VDAC protein is thought to form the major pores through which adenine nucleotides are transferred through the outer mitochondrial membrane. VDAC has also been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex，formed by VDAC，ANT，and CypD is thought to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes ~31 kDa VDAC/Porin from samples of human， mouse， rat， bovine， pig， and rabbit origins.
免疫原
Synthetic peptide surrounding amino acid 189 of human VDAC
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠、牛、兔种属来源的VDAC/Porin蛋白发生免疫反应.
保存建议
提供的VDAC/Porin抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该VDAC/Porin抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
