KiSS-1 has been reported to suppress metastases of melanomas and breast carcinomas without affecting tumorigenicity. Human KiSS-1 transcripts are predominately expressed in the brain and placenta. Expression of KiSS-1 reduces the level of NFkB p50/p65 binding to the MMP9 promoter and correlates with diminished expression of the 92 kDa type IV collagenase （MMP-9）. KiSS-1 may regulate events downstream of cell-matrix adhesion in mechanisms involving cytoskeletal reorganization.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. Jurkat cell lysate can be used as a positive control. The antibody recognizes 16 kDa human KiSS-1 in Western blot analysis with Jurkat cell lysate. Blocking peptide （Cat.# 3590BP-50） is available separately.
免疫原
Synthetic peptide surrounding amino acid 17 of mouse KiSS-1
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的KiSS-1蛋白发生免疫反应.
保存建议
提供的KiSS-1抗体产品为100 ug 无色溶液，其浓度为0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该KiSS-1抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
