The IRAK family members play an important role in IL-1R/TLR mediated inflammatory responses and in innate immunity. IRAK-4 is a novel member in the IRAK family. Over expression of IRAK-4 activates NFkB and MAPK pathways. Animas and human lacking IRAK-4 are impaired in their responses to viral and bacterial challenges.
应用类型
Western blotting （2-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes 50 kDa human IRAK-4. Reactivity of the antibody to other species has not been tested.
免疫原
Synthetic peptide mapping to the C-terminus of human IRAK-4
来源宿主
兔
反应性
经检测验证，可与人种属来源的IRAK-4蛋白 发生免疫反应.
保存建议
提供的IRAK-4抗体 产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该IRAK-4抗体 产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
