TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrates that this relatively small molecule is a fully transformed cell lines. Recently，a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by biding to TRAF1，2，and 3. TweakR mRNA is upregulated during tissue regeneration in aorta and liver. It may also play a role in vascular cell migration and angiogenesis.
应用类型
Western blot analysis （1-4 ug/ml）. However， the optimal conditions should be determined individually.
