Both p44 and p42 MAP kinases （Erk1 and Erk2） function in a protein kinase cascade that plays a critical role in the regulation of cell growth and differentiation. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine at the sequence T*EY* by a single upstream MAP kinase kinase （MEK）.
应用类型
Western blotting （1 ug/ml）， immunoprecipitation （10-20 ug/ml）， and Immunohistochemistry （10-20 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes p44/42 MAP kinase （Erk1/Erk2） of human， mouse， and rat origins.
