The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components，including collagen，gelatin，fibronectin，laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester，lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. Unlike other members of the MMP family，MMP-8 is expressed exclusively in inflammatory conditions. MMP-8 is also the predominant collagenase expressed in ulcers and healing wounds.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 448 of rat MMP-8
