The matrix metalloproteinases （MMP） are a family of peptidase enzymes responsible for the degradation of extracellular matrix components，including collagen，gelatin，fibronectin，laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester，lipopolysaccharide （LPS） or staphylococcal enterotoxin B （SEB）. MMP catalysis requires both calcium and zinc. Unlike other members of the MMP family，MMP-8 is expressed exclusively in inflammatory conditions. MMP-8 is also the predominant collagenase expressed in ulcers and healing wounds.
应用类型
Western blotting （1-4 ug/ml）， immunoprecipitation （10-20 ug/ml）， and Immunohistochemistry （15-25 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes latent （85 kDa） and active forms （25-65 kDa） of MMP8 from human， mouse， and rat origins.
免疫原
Synthetic peptide mapping to the hinge region of the human MMP-8 sequence
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的MMP-8蛋白 发生免疫反应.
保存建议
提供的MMP-8抗体 产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有50%甘油， 1% BSA和0.02%硫柳汞的PBS缓冲液中.请将该MMP-8抗体 产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
