GSK-3 is a serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 has been implicated in the regulation of cell fate and in the Wnt signaling pathway. GSK-3 plays an important role in the PI3 kinase and Akt mediated cell survival pathways，and its activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3 and Ser9 of GSK-3B.
应用类型
Western blot analysis （1-2 ug/ml）， and Immunohistochemistry （20-30 ug/ml）. However， the optimal conditions should be determined individually. The phospho-GSK-3/B （Ser21/9） antibody detects GSK-3 only when phosphorylated at Ser21 of GSK-3 or Ser9 of GSK-3B.
免疫原
Synthetic phospho-peptide derived from human GSK-3a
