Rad17 is an essential component of cell cycle checkpoints activated by DNA damage and disruption of DNA replication. DNA lesions such as single- and double-strand breaks，inter- and intra-strand cross-links，and base modifications hamper transcription and replication，resulting in cell cycle arrest，apoptosis，and mutagenesis. Phosphorylation of Rad17 at Ser635 and Ser645 is a critical early event during checkpoint signaling in DNA damaged cells.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 645 of human Rad17
