Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer’s disease，probably functioning through its associated g-secretase activity for amyloid-B protein processing. Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed N-terminal （34 kDa） and C-terminal （~20 kDa） fragments.
应用类型
Western blotting （2-4 ug/ml）， immunoprecipitation （20 ug/ml）， and Immunohistochemistry （20 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes Presenilin 2 of human， mouse， and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 333 of human presenilin 2
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的Presenilin 2蛋白发生免疫反应.
保存建议
提供的Presenilin 2抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有50%甘油， 1% BSA和0.02%硫柳汞的PBS缓冲液中.请将该Presenilin 2抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
