To date，at least ten members of the Toll family have been identified. TLRs recognize molecular patterns associated with microbial pathogens and induce antimicrobial immune response. TLR3 recognizes double-stranded (ds) RNA，induces the activation of NF-kB，throμgh MyD88-dependent and -independent pathways，and the production of type I interferons (IFNs). Similar to several other members of the TLR family，TLR3 has been reported to be expressed at a very low level on the surface of human fibroblast cell lines.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 805 of mouse TLR3
