ILKs (Integrin-linked kinases) in combination with integrins and growth factors regulate cell survival，cell cycle，cell-cell adhesion and cell motility. ILK functions as a scaffold bridging the extra-cellular matrix (ECM) and growth factor receptors to the actin cytoskeleton throμgh interactions with integrin，PINCH (which links ILK to the RTKs via Nck2)，CH-ILKBP and affixin. ILK phosphorylates several cellular targets including Akt，GSK-3，myosin light chain 2，as well as affixin. These phosphorylation events are key regulatory steps in modulating the activities of the targets.
应用类型
Western blot, Immunohistochemistry
免疫原
Synthetic peptide corresponding to the C-terminus of human ILK-1
