Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups，CXCR and CCR，based on the 2 major classes of chemokines. One of the CCR receptors，CCR3 （eotaxin receptor），is expressed on eosinophils and certain T cell population respond to a variety of CC chemokines apart from eotaxin，including RANTES，monocyte chemotactic protein （MCP）-2，MCP-3，and MCP-4. CCR3 facilitated infection by a more restricted subset of primary viruses，and binding of the CCR3 ligand，eotaxin，and inhibited infection by these isolates.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually.
免疫原
Synthetic peptide surrounding amino acid 332 of rat CCR3
来源宿主
兔
反应性
经检测验证，可与人种属来源的CCR3蛋白发生免疫反应.
保存建议
提供的CCR3抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该CCR3抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
