Heat shock proteins （HSPs） are ubiquitously expressed in all organisms. A major function of HSP90 and other HSPs is to act as molecular chaperones. HSP90 forms a complex with glucocorticoid receptor （GR）， rendering the non ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP56 or cyclophilin-40， forming an aporeceptor complex. HSP90 also exists as a dimer with other proteins such as p60/sti1 and p23， forming an aporeceptor complex with estrogen and androgen receptors.
应用类型
Western blotting （0.5-4 ug/ml）， in immunoprecipitation （10-20 ug/ml） and Immunohistochemistry （frozen sections， 10-20 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes Hsp90α and Hsp90β of human， mouse， and rat origins.
免疫原
Synthetic peptide surrounding amino acid 714 of human Hsp90
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的Hsp90蛋白发生免疫反应.
保存建议
提供的Hsp90抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该Hsp90抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
