- 中文名称
DARPP-32抗体
- 英文名字
- DARPP-32 Antibody, PPP1R1B, DARPP32, DARPP-32, FLJ20940
- 供应商
- BioVision
- 产品货号
- 3386-100
- 产品报价
- ￥3600/100 μg
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- DARPP-32 (dopamine and cyclic AMP-regulated phosphoprotein) is a cytosolic protein highly enriched spiny neurons of the neostriatum. DARPP-32 is a bifunctional signal transduction molecule that controls serine/threonine kinase and serine/threonine phosphatase activity depending on the phosphrylation state of the protein. Dopamine stimulates phosphorylation of DARPP-32 through D1 receptors and activation of PKA. PKA phosphorylation of DARPP-32 at threonine 34 converts it into an inhibitor of protein phosphatase 1. DARPP-32 is converted into an inhibitor of PKA when phosphorylated at threonine 75 by cyclin-dependent kinase 5 (cdk5). Mice containing a targeted deletion of the DARPP-32 gene exhibit an altered biochemical, electrophysiological and behavioral phenotype.
- 应用类型
- Western blotting (0.5-4
- 免疫原
- Synthetic peptide derived from human DARPP-32
- 来源宿主
- 反应性
- 保存建议
- 其他
- BioVision
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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