Transcription factor CREB binds the cAMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters，hormones，membrane depolarization，and growth or neurotrophic factors. Protein kinase A and the calmodulin-dependent protein kinase CaMKII stimulate CREB phosphorylation at Ser133，a key regulatory site controlling transcriptional activity. Phosphorylation at Ser133 is also mediated by p44/42 MAP kinase，p90RSK，p38 MAP kinase and MSK1. CREB appears to play an important role in learning and memory in both flies and mice.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 109 of rat CREB
