ALK (anaplastic lymphoma kinase) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. The NPM-ALK is a constitutively active oncogenic tyrosine kinase associated with anaplastic lymphoma. Activation of PLCgamma by NPM-ALK has been sμggested as a crucial step for this lymphoma-associated oncogenic tyrosine kinase.
应用类型
Western blot
免疫原
Synthetic peptide corresponding to C-terminus of human ALK
